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Key Findings Archive

December 2011

A randomized experiment to examine unintended consequences of dietary supplement use among daily smokers: taking supplements reduces self-regulation of smoking

The use of dietary supplements may lead smokers to smoke more cigarettes under the false belief that the vitamins mitigate the risk. Link to Abstract

'Closet' quit attempts: prevalence, correlates and association with outcome

Keeping quiet about the fact that one is trying to stop smoking is very common and does not appear to hinder the chances of success. Link to Abstract

Impact of the removal of misleading terms on cigarette pack on smokers' beliefs about 'light/mild' cigarettes: cross-country comparisons

Despite the removal of "light/mild" labels from cigarette packaging, alternative labels such as "smooth" and "fine" and design features such as lighter colours are enough to maintain the belief that "light" cigarettes are less harmful than regular ones. Link to Abstract

Cannabis use and cognitive function: 8-year trajectory in a young adult cohort

Stopping regular cannabis use appears to improve the ability to remember information that has just been learned. Link to Abstract

The increasing mortality burden of liver disease among opioid-dependent people: cohort study

In the 30 years since first entering treatment, liver disease has been found to be the most common cause of death among opioid-dependent people in Australia. Link to Abstract

Co-occurrence of obsessive-compulsive disorder and substance use disorder in the general population

Individuals diagnosed with obsessive-compulsive disorder are more likely to suffer from substance use disorder than those diagnosed with non-obsessive-compulsive psychological disorders; this is particularly true of men. Link to Abstract

Alcoholics Anonymous attendance, decreases in impulsivity and drinking and psychosocial outcomes over 16 years: moderated-mediation from a developmental perspective

Among people attending Alcoholics Anonymous, a decrease in impulsivity is associated with fewer alcohol-related problems. Link to Abstract

Treatment outcomes of a stage 1 cognitive-behavioral trial to reduce alcohol use among human immunodeficiency virus-infected out-patients in western Kenya

Cognitive-behavioural therapy, delivered by paraprofessional counsellors, appears to be effective in reducing alcohol use among HIV- infected Kenyan out-patients. Link to Abstract

Non-medical prescription use increases the risk for the onset and recurrence of psychopathology: results from the National Epidemiological Survey on Alcohol and Related Conditions

The non-medical use of prescription medications that affect the central nervous system increases the risk for the onset and recurrence of psychopathology. Link to Abstract

The Örebro prevention programme revisited: a cluster-randomized effectiveness trial of programme effects on youth drinking

The "Örebro prevention programme", as currently delivered in Sweden, does not appear to reduce or delay youth drunkenness. Link to Abstract

Reducing the legal blood alcohol concentration limit for driving in developing countries: a time for change? Results and implications derived from a time-series analysis (2001-10) conducted in Brazil&

When Brazil reduced the legal limit for blood alcohol when driving it reduced the numbers of deaths caused by traffic accidents Link to Abstract

November 2011

The timing of smoking onset, prolonged abstinence and relapse in men: a prospective study from ages 18 to 32 years 

Even after long periods of abstinence from smoking, relapses continue to erode quit success. Starting to smoke early in adolescence appears to be linked to lower likelihood of quitting later in adulthood. Link to Abstract

Electronic cigarette: users profile, utilization, satisfaction and perceived efficacy

E-cigarettes are used both as an aid to reducing and quitting smoking and by former smokers to avoid relapse, in much the same way that people use nicotine replacement therapy. Link to Abstract

Planned quit attempts among Ontario smokers: impact on abstinence

Among smokers in Ontario, most quit attempts are planned and planners are more likely to use quit aids; however, planning does not appear to increase the likelihood of success. Link to Abstract

Long-term effects of a community-based intervention: 5-year follow-up of 'Clubs against Drugs'

The 'Clubs against Drugs' community-based intervention programme, a systems approach to prevention, appears to increase the frequency and effectiveness of club doormen's interventions to tackle obviously drug-intoxicated guests.  Link to Abstract

Mephedrone: use, subjective effects and health risks

Mephedrone has a high abuse and health risk liability, with increased tolerance, impaired control and a compulsion to use being the predominant reported dependence symptoms. Link to Abstract

The impact of needle and syringe provision and opiate substitution therapy on the incidence of hepatitis C virus in injecting drug users: pooling of UK evidence

In the UK, opiate substitution therapy and a high coverage of needle and syringe programmes appears to have substantially reduced the risk of hepatitis C virus transmission among injecting drug users. Link to Abstract

The effect of neighborhood deprivation and residential relocation on long-term injection cessation among injection drug users (IDUs) in Baltimore, Maryland

Living in a deprived neighbourhood appears to undermine attempts to stop injecting illicit drugs. Relocating out of these neighbourhoods appears to be helpful in promoting behaviour change. Link to Abstract

The role of alcohol in the Russian mortality crisis

Much of the 1990 to 1994 rise in Russian mortality appears to have been due to the increase in population alcohol consumption. Link to Abstract

Drinking behaviour among men and women in China: the 2007 China Chronic Disease and Risk Factor Surveillance

Excessive drinking, frequent drinking and binge drinking behaviour have reached epidemic proportions among current drinkers in China. Link to Abstract

DSM-IV to DSM-5: the impact of proposed revisions on diagnosis of alcohol use disorders

The proposed DSM-5 revisions to diagnosis of alcohol use disorders would exclude as cases individuals who drink at hazardous levels but show no other signs of dependence or alcohol problems but include individuals with relatively low levels of dependence Link to Abstract

Housewife or working mum--each to her own? The relevance of societal factors in the association between social roles and alcohol use among mothers in 16 industrialized countries

In countries with relatively high gender-income equality, the combination of motherhood, paid labour and partnership appears to be associated with decreased alcohol consumption; in countries with lower gender-income equality, this role combination does not appear to have the same effect. Link to Abstract

October 2011

Substance use and exercise participation among young adults: parallel trajectories in a national cohort-sequential study

Increased participation in sports, athletics or exercising is related to significantly lower substance use at age 18 and into early adulthood. Link to Abstract

Examining gender differences in emerging tobacco use using the adolescents' need for smoking scale

Canadian girls score higher than boys on measures of emotional dependence and social attitudes associated with tobacco smoking. Link to Abstract

The dynamics of the urge-to-smoke following smoking cessation via pharmacotherapy

The chances of success of quit attempts appear to be influenced not only by the strength of urges to smoke but by the way that they change over time Link to Abstract

The impact of the introduction of smoke-free legislation on prescribing of stop-smoking medications in England

While prescriptions of all smoking cessation medications in England increased in the months leading up to the introduction of smoke-free legislation, this increase was not sustained afterwards. Link to Abstract

Cost effectiveness of interventions to reduce relapse to smoking following smoking cessation

Treatments aimed at preventing relapse to smoking after a quit attempt (such as nicotine replacement therapy) appear cost effective when used in routine clinical care. Link to Abstract

Cocaine-related attentional bias following trauma cue exposure among cocaine dependent in-patients with and without post-traumatic stress disorder

Cocaine appears to serve an emotion-regulating function among post-traumatic stress disorder patients. Link to Abstract

Effects of a randomized contingency management intervention on opiate abstinence and retention in methadone maintenance treatment in China

In China, "contingency management" - the use of motivational incentives - appears to improve opiate abstinence and treatment retention in methadone maintenance treatment clinics. Link to Abstract

The social norms of birth cohorts and adolescent marijuana use in the United States, 1976-2007

Individuals in birth cohorts that are more disapproving of marijuana use are less likely to use, independent of their personal attitudes towards marijuana use. Link to Abstract

Sexual transmissibility of HIV among opiate users with concurrent sexual partnerships: an egocentric network study in Yunnan, China

In China, concurrent sexual partnerships are common among both injection drug users and non-injection drug users; these concurrent sexual partnerships may serve as a bridging group to transmit HIV from high-risk populations to the general population. Link to Abstract

Access to alcohol outlets and harmful alcohol consumption: a multi-level study in Melbourne, Australia

In Australia, an increased number of off-premises alcohol outlets in an area is associated with a greater risk of harmful alcohol consumption. Link to Abstract

Extended telephone-based continuing care for alcohol dependence: 24-month outcomes and subgroup analyses

The benefits of an extended telephone-based continuing care programme to treat alcohol dependence did not persist after the end of the intervention. Link to Abstract

Brief interventions in routine health care: a population-based study of conversations about alcohol in Sweden

In Sweden, brief interventions to reduce alcohol consumption are more effective when conversations with health-care professionals are longer and include advice on how to cut down on drinking. Link to Abstract

September 2011

Effectiveness of a stepped primary care smoking cessation intervention: cluster randomized clinical trial (ISTAPS study) 

In primary care settings, a "stepped" smoking cessation intervention appears to significantly increase smoking abstinence, compared with a brief intervention. Link to Abstract

Australian smokers' and recent quitters' responses to the increasing price of cigarettes in the context of a tobacco tax increase

In Australia, an increase in cigarette prices does not appear to result in smokers moving to cheaper cigarette products. Instead, the majority of smokers indicate a positive change in their smoking-related thoughts and behaviours as a result of the prices increase. Link to Abstract

Nicotine dependence, abuse and craving: dimensionality in an Israeli sample

The various criteria conventionally applied to define dependence on nicotine, such as craving and experience of withdrawal symptoms, appear to be sufficiently closely related to each other as to be regarded as a single underlying condition that varies in severity. Link to Abstract

Reaching out towards cannabis: approach-bias in heavy cannabis users predicts changes in cannabis use

Heavy cannabis users appear to have an automatically triggered tendency to approach rather than avoid cannabis-related stimuli; those with stronger tendencies to approach are more likely to increase cannabis use. Link to Abstract

Age moderates non-genetic influences on the initiation of cannabis use: a twin-sibling study in Dutch adolescents and young adults

Familial similarities in the initiation of cannabis use appear to be influenced by both environmental and genetic factors, with the influence of environmental factors increasing - and genetic factors decreasing - from early adolescence to young adulthood. Link to Abstract

Physical and mental health in severe opioid-dependent patients within a randomized controlled maintenance treatment trial

Both heroin-assisted and methadone maintenance treatments appear to improve physical and mental health among severe opioid-dependent patients, with heroin-assisted treatment producing the best results. Link to Abstract

Cannabis and social welfare assistance: a longitudinal study

In Norway, the use of cannabis is linked with subsequent receipt of social welfare assistance, although it is unclear whether this welfare assistance is a consequence of cannabis use or of cultural factors and the illegal status of the cannabis. Link to Abstract

Intoxicated workers: findings from a national Australian survey

In Australia, alcohol use at work appears to be widespread, with more than one in twenty workers admitting to having worked under the influence of alcohol. Link to Abstract

The relationship between serious injury and blood alcohol concentration (BAC) in fatal motor vehicle accidents: BAC=0.01% is associated with significantly more dangerous accidents than BAC

In the US, the severity of life-threatening motor vehicle accidents increases significantly at blood alcohol concentrations that are far lower than the current legal limit of 0.08 percent. Link to Abstract

Surveying the range and magnitude of alcohol's harm to others in Australia

Seventy percent of Australians report being negatively affected by other people's drinking; these negative effects range from noise and fear to physical abuse, sexual coercion and social isolation. Link to Abstract

August 2011

Social gradient in initiation and transition to daily use of tobacco and cannabis during adolescence: a retrospective cohort study

Although adolescents from high socio-economic backgrounds are at risk of tobacco and cannabis experimentation, they are less likely to engage in daily use than adolescents from lower socio-economic backgrounds. Link to Abstract

Prescribing of nicotine replacement therapy to adolescents in England

Despite the recent inclusion of 12-17 year olds in the marketing licence for nicotine replacement therapy in England, prescriptions to adolescents remain low. Link to Abstract

Plain packaging increases visual attention to health warnings on cigarette packs in non-smokers and weekly smokers but not daily smokers

Among non-smokers and non-daily cigarette smokers, plain packaging appears to increase visual attention towards health warning information and away from brand information. Link to Abstract

Hypothalamic-pituitary-adrenal axis reactivity to social stress and adolescent cannabis use: the TRAILS study

Among adolescents, low levels of reactivity to social stress are associated with repeated and lifetime cannabis use. Link to Abstract

Methamphetamine users show greater than normal age-related cortical gray matter loss

Age-related cortical gray matter loss is greater than normal in methamphetamine users, suggesting the possibility of an accelerated decline in their mental functioning. Link to Abstract

The pharmacodynamic and pharmacokinetic profile of intranasal crushed buprenorphine and buprenorphine/naloxone tablets in opioid abusers

The abuse potential of crushed buprenorphine and buprenorphine/naloxone tablets - used in the treatment of opioid dependence - taken by the intranasal route appears low. Link to Abstract

Socio-economic determinants of drugged driving - a register-based study

In Finland, a disadvantaged socio-economic background increases the likelihood of driving while under the influence of drugs for all substance use groups. Low education, unemployment and receiving a disability pension are particularly strong predictors. Link to Abstract

Mortality among a cohort of drug users after their release from prison: an evaluation of the effectiveness of a harm reduction program in Taiwan

Among ex-prisoners in Taiwan with a history of opiate injecting, enrolment and continued participation in methadone maintenance treatment is associated with substantially lower mortality. Link to Abstract

Gender differences in the impact of families on alcohol use: a lagged longitudinal study of early adolescents

Family environment appears to impact differently upon the alcohol use of male versus female adolescents. While an emotionally close relationship to mothers is associated with less frequent drinking in females, parental disapproval of alcohol is a better predictor of reduced drinking in males. Link to Abstract

Similar profile of cognitive impairment and recovery for Aboriginal Australians in treatment for episodic or chronic alcohol use

Among Aboriginal Australians, episodic or "binge" drinking is associated with similar patterns of cognitive impairment and recovery as chronic alcohol use. Link to Abstract

July 2011

Does the introduction of comprehensive smoke-free legislation lead to a decrease in population smoking prevalence?

Across Canada and the US, smoke-free legislation does not appear to have had an impact on existing smoking trends, although it has increased the decline of smoking prevalence is some regions. Link to Abstract

Prospective predictors of quitting behaviours among adult smokers in six cities in China: findings from the International Tobacco Control (ITC) China Survey

Contrary to findings in other South East Asian countries, neither low nicotine dependence nor high-self efficacy appear to predict successful smoking cessation in China. Link to Abstract

Relative performance of common biochemical indicators in detecting cigarette smoking

In areas with strong smoke-free laws, a breath carbon monoxide level of 5 parts per million or more is effective at identifying someone as a cigarette smoker. Link to Abstract

Prescribing of smoking cessation medication in England since the introduction of varenicline

Since its introduction in England, varenicline has become the most commonly prescribed smoking cessation medication after nicotine replacement therapy. Despite this popularity, varenicline has not led to an increase in the overall prescription rates for smoking cessation medication. Link to Abstract

Employment-based reinforcement of adherence to depot naltrexone in unemployed opioid-dependent adults: a randomized controlled trial

Employment-based reinforcement appears to increase adherence to depot naltrexone, a drug that blocks the effects of opioids, among unemployed opioid-dependent adults. Link to Abstract

Deviant socialization mediates transmissible and contextual risk on cannabis use disorder development: a prospective study

Deviant socialization resulting from transmissible risk (genetic or parental upbringing risk factors) and poor parent-child relationships is integral to the development of cannabis use disorder in young adulthood. Link to Abstract

Pill content, dose and resulting plasma concentrations of 3,4-methylendioxymethamphetamine (MDMA) in recreational 'ecstasy' users

Among ecstasy users in Australia, the use of multiple ecstasy pills in one session is common, likely resulting in a greater exposure of the brain to MDMA than is predicted in single-dose studies. Link to Abstract

Drug violations and aviation accidents: findings from the US mandatory drug testing programs

Although rare, illegal drug use among aviation employees is associated with a significantly increased risk of involvement in an aviation accident. Link to Abstract

Effects of major depression on crack use and arrests among women in drug court

Among women attending drug court, current major depression, but not past major depression, appears to increase the risk of crack cocaine use. Link to Abstract

Associations between drinking motives and changes in adolescents' alcohol consumption: a full cross-lagged panel study

In the Netherlands, adolescents who are motivated to drink alcohol for social reasons - such as "fitting in" and "having fun" - appear more likely to drink heavily after a year than adolescents who drank to enhance their mood or cope with negative emotion Link to Abstract

Does readiness to change predict in-session motivational language? Correspondence between two conceptualizations of client motivation

The use of motivational language by patients during counselling for excessive alcohol consumption does not appear to be a good predictor of their actual readiness to change their drinking behaviour. Link to Abstract

The prevalence of alcohol use disorders among night-time weekend drivers

The majority of drunk drivers on US roads during weekend evenings and nights do not suffer from alcohol use disorders, but can be considered heavy drinkers. Link to Abstract

Alcohol-related discussions in health care--a population view

Despite reporting positive feelings about alcohol-related discussions in healthcare settings, relatively few people in Finland are asked about alcohol consumption by healthcare professionals, and even fewer are offered advice. Link to Abstract

June 2011

Does improved access and greater choice of nicotine replacement therapy affect smoking cessation success? Findings from a randomized controlled trial

Offering smokers who want to quit a wide range of nicotine replacement therapy does not appear to produce better results than offering a narrower selection of reduced cost nicotine replacement therapy. Link to Abstract

Beyond light and mild: cigarette brand descriptors and perceptions of risk in the International Tobacco Control (ITC) Four Country Survey

Although the words 'light' and 'mild' are banned, smokers in western countries continue to believe that some cigarette brands are less harmful than others. These beliefs are based on the descriptive words and designs used in cigarette marketing. Link to Abstract

A randomized controlled trial of a smoking reduction plus nicotine replacement therapy intervention for smokers not willing to quit smoking

In smokers with no immediate plans to quit, smoking reduction programmes with behavioural support and nicotine replacement therapy are more effective than brief advice to quit Link to Abstract

Empirically derived subtypes of opioid use and related behaviours

There are five distinct categories of opioid use and related behaviour, with each category - particularly the most severe, early-onset category - revealing significant genetic influences on the characteristics of an individual's opioid use. Link to Abstract

The validity of DSM-IV cannabis abuse and dependence criteria in adolescents and the value of additional cannabis use indicators

DSM's current distinction between cannabis abuse and cannabis dependence has limited use for diagnosing adolescents. The two sets of criteria do not reflect two distinct aspects of cannabis-related problems, but instead constitute a single underlying diso Link to Abstract

Affective disorders and anxiety disorders predict the risk of drug harmful use and dependence

Patients with affective disorders and anxiety disorders have an increased risk of developing substance abuse problems, although it is unclear whether these disorders lead to substance abuse problems, or whether both are symptoms of a common cause. Link to Abstract

Staff regard towards working with substance users: a European multi-centre study

In Europe, health professionals - particularly those in primary care - appear to have a lower regard for treating substance users than for treating patients with other chronic conditions. Link to Abstract

The role of person-environment interactions in increased alcohol use in the transition to college

In the transition from high school to college, sensation seeking students from protective high school environments experience more alcohol-related problems than those from less protective environments. Link to Abstract

Alcohol expectancy moderates attentional bias for alcohol cues in light drinkers

While light drinkers only show increased attention to pictures that are alcohol-related when they are expecting alcohol, heavy drinkers show a preference for alcohol-related pictures regardless of whether they are expecting alcohol. Link to Abstract

Alcohol's harm to others: reduced wellbeing and health status for those with heavy drinkers in their lives

As is widely believed, heavy drinking adversely affects the health and personal well-being of others who are close to the heavy drinker. Link to Abstract

May 2011

Comorbid psychiatric disorders and nicotine dependence in adolescence

Psychiatric disorders have a stronger influence on the onset of nicotine dependence in adolescents than nicotine dependence has on the onset of psychiatric disorders. Disruptive behaviour disorders appear to be a particularly important precursor and consequence of nicotine dependence. Link to Abstract

Influence of traditional tobacco use on smoking cessation among American Indians

When compared with other racial/ethnic groups, American Indians appear to have a low awareness of the use of pharmacotherapy - such as nicotine replacement therapy - to aid smoking cessation. Link to Abstract

Genetics of the association between intelligence and nicotine dependence: a study of male Swedish twins

Nicotine dependence and intelligence are only weakly associated. This association does not appear to be due to common genetic factors. Link to Abstract

Associations of CYP2A6 genotype with smoking behaviors in southern China

Among Chinese smokers, a variant of the CYP2A6 gene leading to reduced rate of nicotine metabolism is associated with later smoking initiation, fewer cigarettes smoked per day, shorter smoking duration but reduced likelihood of smoking cessation. Link to Abstract

Clinical experience with the treatment of hepatitis C infection in patients on opioid pharmacotherapy

Treatment for Hepatitis C infection can be successful in patients on opioid substitution therapy, even if they are active injectors, and is not associated with any major safety concerns. Link to Abstract

Outreach screening of drug users for cirrhosis with transient elastography

'Transient elastography' - a non-invasive procedure - has the capacity to identify severe liver fibrosis in a significant proportion of drug users with hepatitis C infections, making it a feasible screening tool for cirrhosis among drug users. Link to Abstract

Employment-based abstinence reinforcement as a maintenance intervention for the treatment of cocaine dependence: post-intervention outcomes

Although abstinence-contingent employment appears to reduce cocaine use in cocaine dependent patients, there is a high rate of relapse once the abstinence contingency of their employment is discontinued. Link to Abstract

Impaired conditional reasoning in alcoholics: a negative impact on social interactions and risky behaviors?

The capacity for 'conditional reasoning' (using if-then rules) of patients being treated for alcohol dependence, including reasoning about social contracts and emotional intelligence, appears to be impaired. Link to Abstract

An evaluation of the proposed DSM-5 alcohol use disorder criteria using Australian national data

Alcohol use disorders have a low correlation with the 'substance-related legal problems' criterion used in the DSM diagnosis, supporting the removal of the criterion. Although alcohol use disorders have a high correlation with the proposed 'craving' crite Link to Abstract

Randomized controlled trial of a brief intervention for unhealthy alcohol use in hospitalized Taiwanese men

In Taiwan, a brief in-hospital interventions has been found to reduce alcohol consumption among hospitalised men who drink heavily or have been diagnosed with alcohol use disorders. Link to Abstract

A longitudinal analysis of alcohol outlet density and domestic violence

Rates of domestic violence appear to correlate positively with the density of alcohol outlets in the local area, particularly those with off premise alcohol licenses. Link to Abstract

April 2011

The role of desire, duty and intention in predicting attempts to quit smoking

Although 'duty' - the belief that one ought to quit smoking - appears to be the most commonly reported motive for quitting, both 'desire' and 'intention' to quit are better predictors of quit attempts, with 'duty' even appearing to mitigate their effects. Link to Abstract

Adjustment of nicotine replacement therapies according to saliva cotinine concentration: the ADONIS trial--a randomized study in smokers with medical comorbidities

Among smokers with smoking-related illnesses, tailoring nicotine replacement therapy according to the concentration of cotinine - a biomarker for tobacco smoke exposure - in the patient's saliva does not appear more effective than standard nicotine replac Link to Abstract

Treating heavy smokers in primary care with the nicotine nasal spray: randomized placebo-controlled trial

Treating heavy smokers in primary care with nicotine nasal spray compared with a placebo, significantly increases the rate of successful quit attempts, and is particularly effective among those highly dependent on nicotine. Link to Abstract

The population impact of smoke-free workplace and hospitality industry legislation on smoking behaviour. Findings from a national population survey

In the Netherlands, a workplace ban on smoking appears to have been more effective than a hospitality ban in reducing the prevalence of smoking and increasing the rate of successful quit attempts. Link to Abstract

Increasing US mortality due to accidental poisoning: the role of the baby boom cohort

Over the past decade there has been a sharp increase in accidental poisoning deaths in the US. While a baby boom cohort effect is likely responsible for this increase among black Americans, among white Americans it appears that a historical period effect - possibly the rise in non-medical pharmaceutical drug use - has contributed to this rise in deaths. Link to Abstract

Modelling the adverse effects associated with ecstasy use

Long-term ecstasy use increases the likelihood of adverse effects, such as paranoia, poor general health and irritability, particularly when the drug is consumed with alcohol. These adverse effects decrease with the period of abstinence from the drug. Link to Abstract

The association between spending on methamphetamine/amphetamine and cannabis for personal use and earnings from acquisitive crime among police detainees in New Zealand

In New Zealand there is a positive correlation between earnings from property crime and levels of both methamphetamine/amphetamine and cannabis use. While this relationship also exists between methamphetamine/amphetamine use and drug dealing, earnings from drug dealing are negatively associated to levels of cannabis use. Link to Abstract

Residual neurocognitive features of long-term ecstasy users with minimal exposure to other drugs

In contrast to previous findings, there is little evidence of decreased cognitive performance in long-term ecstasy users. Link to Abstract

Impact on alcohol-related mortality of a rapid rise in the density of private liquor outlets in British Columbia: a local area multi-level analysis

The large increase in numbers of privately owned liquor stores in British Columbia between 2003 and 2008 was associated with a significant local-area increase in alcohol-related deaths. Link to Abstract

The effects of a large reduction in alcohol prices on hospitalizations related to alcohol: a population-based natural experiment

In Finland, a reduction in the price of alcohol in 2004 was associated with an increase in chronic hospitalization rates among 50-69 year olds. This increase was largely due to a rise in alcohol-related mental and behavioural disorders. Link to Abstract

Types of drinkers and drinking settings: an application of a mathematical model

The level of social interaction between light, moderate and heavy drinkers and the traffic between low-risk and high-risk drinking venues are important determinants of changes in drinking patterns among US college students. Link to Abstract

Inverse association of the obesity predisposing FTO rs9939609 genotype with alcohol consumption and risk for alcohol dependence

The genotype which predisposes to obesity is also associated with protection from alcohol dependence, lower alcohol consumption and less intense cigarette smoking. Link to Abstract

The price of a drink: levels of consumption and price paid per unit of alcohol by Edinburgh's ill drinkers with a comparison to wider alcohol sales in Scotland

Drinkers in Edinburgh with alcohol-related illnesses pay an average of £0.29 less per unit of alcohol than the general Scottish population, with those paying the lowest prices consuming the greatest amounts of alcohol. Link to Abstract

Interventions for disorder and severe intoxication in and around licensed premises, 1989-2009

Server training appeared to be successful at reducing alcohol-related violence in and around licensed premises. However, there is limited evidence that premises level interventions are effective at reducing intoxication or related disorder. Link to Abstract

March 2011

Probability and predictors of remission from life-time nicotine, alcohol, cannabis or cocaine dependence: results from the National Epidemiologic Survey on Alcohol and Related Conditions

The vast majority of nicotine, alcohol, cannabis or cocaine dependent individuals achieve remission at some point in their lives, with males, Blacks and those with personality disorders exhibiting the lowest rates of remission. Link to Abstract

Effect of compliance with nicotine gum dosing on weight gained during a quit attempt

During the first 30 days of a quit attempt, smokers who use more pieces of nicotine gum experience less weight gain. This relationship is not seen for smokers on nicotine-free placebo gum. Link to Abstract

An Ecological Momentary Assessment analysis of relations among coping, affect and smoking during a quit attempt

Although stress coping responses during a quit attempt may be effective at lowering stress, they do not appear to protect against smoking or increase the likelihood of quit success. Link to Abstract

Strength of urges to smoke as a measure of severity of cigarette dependence: comparison with the Fagerström Test for Nicotine Dependence and its components

Among English smokers, a simple 'strength of urges' rating appears to be a good predictor of short-term quit success. Link to Abstract

Cigarette tax and public health: what are the implications of financially stressed smokers for the effects of price increases on smoking prevalence?

Although price increases may reduce smoking prevalence among smokers as a whole, financial stress appears to limit the efficacy of price increases among low-income smokers. Link to Abstract

Do cigarette prices motivate smokers to quit? New evidence from the ITC survey

Smokers living in areas with higher cigarette prices and taxes were significantly more motivated to quit and had an increased likelihood of actual quitting. Link to Abstract

Predictors and correlates of reduced frequency or cessation of injection drug use during a randomized HIV prevention intervention trial

HIV prevention interventions that encourage injection drug users to take on the role of peer educator may have the additional benefit of increasing the likelihood of injection cessation. Link to Abstract

Opioid dependence latent structure: two classes with differing severity?

Among in-treatment opioid users, there appears to be two separate classes of individuals, exhibiting distinct patterns of opioid dependence, other substance use and mental health disorders. Link to Abstract

Mortality and HIV transmission among male Vietnamese injection drug users

The mortality rate of male Vietnamese injection drug users is 13 times higher than that of the general population and substantially higher than the mortality rate of injection drug users studied in developed countries. Link to Abstract

Revised dose schema of sublingual buprenorphine in the treatment of the neonatal opioid abstinence syndrome

Administering Buprenorphine to infants was demonstrated to be both safe and effective in the treatment of neonatal opioid abstinence syndrome, with indications of a therapeutic advantage over morphine. Link to Abstract

Neural correlates of verbal learning in adolescent alcohol and marijuana users

While adolescent users of alcohol and marijuana displayed no difference from non-users in their performance on a verbal encoding task, both binge drinkers and combined marijuana and alcohol users did exhibit different brain response patterns. No main effects of marijuana use alone were found. Link to Abstract

Exploring the emergence of alcohol use disorder symptoms in the two years after onset of drinking: findings from the National Surveys on Drug Use and Health

Despite steadily increasing during the first nine months of alcohol use, the emergence of clinical features of alcohol use disorder then appear to plateau or fluctuate during the second year. Link to Abstract

Effects of alcohol portrayals in movies on actual alcohol consumption: an observational experimental study

The portrayal of alcohol consumption in movies appears to increase the alcohol consumption of young males while they are viewing the movie, but not that of female viewers. Link to Abstract

Why target early adolescents and parents in alcohol prevention? The mediating effects of self-control, rules and attitudes about alcohol use

An intervention targeting both young adolescents and their parents appears to be effective in delaying the onset of weekly alcohol use by developing adolescent self-control as well as parental rule-setting. Link to Abstract

Brief alcohol interventions for mandated college students: comparison of face-to-face counseling and computer-delivered interventions

Among American college students who had violated alcohol policies, face-to-face counselling reduced alcohol consumption and related problems more than computer-delivered interventions, particularly in female students. Link to Abstract

Alcohol as a risk factor for sudden infant death syndrome (SIDS)

Alcohol consumption in parents may increase the risk of sudden infant death syndrome. However, it is unclear whether this is due to alcohol impairing parental capacity, or alcohol being a proxy for other risk factors, such as smoking. Link to Abstract

February 2011

Teaching community program clinicians motivational interviewing using expert and train-the-trainer strategies

Both 'expert-led' and 'train-the-trainer' approaches to training clinicians in addiction treatment appear to be more successful than a self-study approach. Link to Abstract

Anxiety diagnoses in smokers seeking cessation treatment: relations with tobacco dependence, withdrawal, outcome and response to treatment

Anxiety diagnoses are common among smokers attempting to quit, and appear to be related to an impaired ability to quit. Link to Abstract

Does extinction of responses to cigarette cues occur during smoking cessation?

For smokers attempting to quit, exposure to available cigarettes is a risk factor for lapsing. However, this risk can be reduced by repeated exposures to available cigarettes without smoking. Link to Abstract

The relationship between addiction and reward bundling: an experiment comparing smokers and non-smokers

Smokers appear to be more likely than non-smokers to prefer small short-term rewards over larger delayed rewards. Link to Abstract

Dizziness and the genetic influences on subjective experiences to initial cigarette use

An individual's initial smoking experience appears to be affected by heritable factors, particularly the experience of dizziness which may be caused by a heritable sensitivity to the chemicals contained in cigarettes. Link to Abstract

Dopamine release in ventral striatum during Iowa Gambling Task performance is associated with increased excitement levels in pathological gambling

Dopamine release appears to be associated with increased excitement levels in pathological gamblers, regardless of their performance in a gambling task. Link to Abstract

Cessation of groin injecting behaviour among patients on oral opioid substitution treatment

Although oral opioid substitution therapy can reduce groin injecting in some patients, groin injecting usually persists despite both treatment and severe health complications. Link to Abstract

The STEP into Action study: a peer-based, personal risk network-focused HIV prevention intervention with injection drug users in Baltimore, Maryland

'STEP into Action', a peer-based training program using the influence of social networks, appeared to reduce behaviour with a high risk of HIV transmission among active injection drug users. Link to Abstract

The roles of law, client race and program visibility in shaping police interference with the operation of US syringe exchange programs

Police interference in American syringe exchange programs is inconsistent, with programs predominantly serving non-white drug users reporting higher levels of police interference. Link to Abstract

Decreased bone density in men on methadone maintenance therapy

Bone density appears to be lower than normal in men, but not women, taking methadone maintenance therapy. Link to Abstract

The course of substance use disorders in patients with borderline personality disorder and Axis II comparison subjects: a 10-year follow-up study

Substance use disorders appear more prevalent among patients also suffering from borderline personality disorder, although remissions in drug use appear common and relatively stable. Link to Abstract

The acute effects of caffeinated versus non-caffeinated alcoholic beverage on driving performance and attention/reaction time

Despite the common belief among young drinkers that caffeinated alcoholic drinks enhance alertness, when compared to non-caffeinated alcoholic drinks they do not appear to improve either driving performance or attention/reaction times. Link to Abstract

Personal, family and social functioning among older couples concordant and discordant for high-risk alcohol consumption

In couples over 65, high-risk drinking and differences in alcohol consumption do not appear to have a negative effect on the quality of marital relationships or family functioning, as they appear to in younger couples. Link to Abstract

Per capita alcohol consumption and ischemic heart disease mortality in a panel of US states from 1950 to 2002

In US adults, consumption of alcohol, and particularly spirits, appears to be associated with an increased rate of ischemic heart disease mortality while beer consumption appears have a protective effect. Link to Abstract

Effects of restricting pub closing times on night-time assaults in an Australian city

Effects of restricting pub closing times on night-time assaults in an Australian city Link to Abstract

Can stand-alone computer-based interventions reduce alcohol consumption? A systematic review

Computer-based interventions appear to be effective at reducing alcohol consumption in both student and non-student populations. Link to Abstract

January 2011

Common and drug-specific genetic influences on subjective effects to alcohol, tobacco and marijuana use

Individual responses to alcohol, tobacco and marijuana use appear to share common genetic influences; drug-specific genetic influences appear to contribute to individual differences in drug response Link to Abstract

Online video game addiction: identification of addicted adolescent gamers

In the Netherlands, approximately 1.5% of all 13-16 year olds can be considered addicted online gamers. Despite addiction-like problems, an association between addictive online gaming and decreased psychosocial health is not evident. Link to Abstract

Use of nicotine replacement therapy for smoking reduction and during enforced temporary abstinence: a national survey of English smokers

The use of nicotine replacement therapy for smoking reduction and temporary abstinence does not appear to reduce the number of cigarettes consumed, when compared with those attempting reduction and temporary abstinence without nicotine replacement therapy. Link to Abstract

Associations between weight change over 8 years and baseline body mass index in a cohort of continuing and quitting smokers

Smokers who quit smoking gain more weight than those who continue smoking; the association between quitting and weight gain is particularly pronounced in those who are already obese. Link to Abstract

Declining alternative reinforcers link depression to young adult smoking

The observed association between depressive symptoms and smoking in young adults may be influenced by a decline in the presence of alternative sources of personal reward in depressive young adults. Link to Abstract

Evening types are more often current smokers and nicotine-dependent--a study of Finnish adult twins

Compared to 'morning types', 'evening types' are more likely to be current smokers and highly nicotine dependent; 'evening types' also have a lower likelihood of quitting smoking. Link to Abstract

The association between use of snus and quit rates for smoking: results from seven Norwegian cross-sectional studies

Consistent with Swedish studies, Norwegian data shows that snus use is associated with an increased probability of being a former compared with a current smoker, suggesting that in Norway snus may have a role in smoking cessation. Link to Abstract

Mephedrone, new kid for the chop?

A study of users of a UK-based dance and clubbing website suggests that mephedrone use is common, particularly among males with the preferred route being intranasal. Link to Abstract

Hepatitis C virus among non-injecting cocaine users (NICUs) in South America: can injectors be a bridge?

Non-injecting cocaine users in South America are vulnerable to Hepatitis C infection, particularly those in an intimate relationship with an intravenous drug using, or HIV positive, partner. Link to Abstract

Impact of jail sanctions during drug court participation upon substance abuse treatment completion

A jail sanction for non-adherence to substance abuse treatment is more likely to achieve successful results in individuals not already acclimatized to incarceration. Link to Abstract

Paternal incarceration and trajectories of marijuana and other illegal drug use from adolescence into young adulthood: evidence from longitudinal panels of males and females in the United States

Paternal incarceration is associated with an increase in marijuana use and the risk of other illegal drug use among adolescents and young adults in the United States. Link to Abstract

Primary care-based intervention to reduce at-risk drinking in older adults: a randomized controlled trial

Although there is evidence to show that interventions reduce unhealthy alcohol use in primary care populations, a multi-component intervention among older adults in primary care did not reduce at-risk drinking, despite reducing alcohol consumption. Link to Abstract

'Alcohol, less is better' project: outcomes of an Italian community-based prevention programme on reducing per-capita alcohol consumption

The 'Alcohol, less is better' project, which is aimed at changing attitudes to alcohol through the involvement of community leaders, appears to reduce alcohol consumption in participants, particularly women Link to Abstract

High alcohol consumption in middle-aged adults is associated with poorer cognitive performance only in the low socio-economic group. Results from the GAZEL cohort study

High alcohol consumption is associated with poor cognitive performance among low socio-economic grou Link to Abstract

Area of residence and alcohol-related mortality risk: a five-year follow-up study

Whilst alcohol-related mortality is higher in the more deprived areas of Northern Ireland, this appears to be due to the characteristics of individuals within the areas, rather than an independent effect of area deprivation. Link to Abstract

Reduction in alcohol consumption and health status

A deterioration in health appears to be an important motive for reducing or stopping alcohol consumption; this may at least partly explain the apparently increased risk of ill health in people who abstain from drinking. Link to Abstract

A meta-analysis of alcohol toxicology study findings among homicide victims

A third of homicide victims appear to have been intoxicated with alcohol at the time of their death but this figure has decreased over time. Link to Abstract

Mortality among regular or dependent users of heroin and other opioids: a systematic review and meta-analysis of cohort studies

Although mortality in opioid-dependent users varies between countries, overdose is the most common cause of death. Link to Abstract